2-[[5-(Substituted-phenyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[1,3-thiazol-2-yl]acetamides: new bi-heterocycles as possible therapeutic agents

An electrophile, N-[1,3-thiazol-2-yl]-2-bromoacetamide [3], was synthesized by the reaction of 1,3-thiazole-2- amine [1] and 2-bromoethanoyl bromide [2] in an aqueous medium. A series of carboxylic acids, 7a-j, were converted into 1,3,4-oxadiazole heterocyclic core, through a series of three steps. The final compounds, 8a-j, were synthesized by stirring 7a-j and 3 in an aprotic polar solvent. The structural elucidation of the synthesized compounds was supported by IR, EI-MS, 1 H-NMR, and 13C-NMR spectral data. Title compounds were evaluated for enzyme inhibition against cholinesterases and alpha-glucosidase enzymes and their cytotoxic behavior was monitored using brine shrimp assay. The enzyme inhibitor potential of compounds was supported by molecular docking studies

Incidence of contrast-induced nephropathy and its contributing factors after cardiac catheterization in type II diabetic patients

Objective: To evaluate the incidence of contrast-induced nephropathy [CIN] and its contributing factors after cardiac catheterization in type II diabetic patients. Study Design: Cross sectional study. Place and Duration of Study: Choudhary Pervaiz Ellahi Institute of Cardiology [CPEIC], Multan for six months, from Aug 2016 to Mar 2017

Material and Methods: This cross sectional study was conducted and completed in the department of cardiology Choudhary Pervaiz Ellahi Institute of Cardiology [CPEIC], Multan for six months [August 2016 to March 2017]. Before start of the study ethical approval was obtained from hospital ethical board/committee; informed consent was taken from patients and their attendants after complete information and they were also ensured about their confidentiality. All collected data was aligned and entered in a computer software SPSS version 23.1 and data was analyzed. Mean +/- SD values were calculated and presented for quantitative data variables like age, similarly frequency [percentages] were calculated and presented for qualitative variable data like gender. After stratification of data, student chi square test was used to see effect modification. A p-value

Results: A total number of 255 patients were included in the study. All patients were admitted for cardiac catheterization. Participants of the study were divided into two groups on the basis of CIN presence. Group A consisted of 210 patients who didn't develop contrast-induced nephropathy [CIN] after catheterization of coronary artery. Group B consisted of 45 patients of CIN after catheterization of coronary artery. It was found that incidence of CIN in diabetic patients with micro-albuminuria was 17.64% [n=45]

Conclusion: Observation of our study found that diabetic patients either with normal baseline creatinine are at an increased risk of developing CIN after angiography of coronary artery

Brimonidine efficacy on intraocular pressure control following Nd: YAG laser capsulotomy

Objective: To determine the efficacy of 0.2% brimonidine eye drops on control of intraocular pressure following Neodymium: Yttrium-Aluminum-Garnet [Nd: YAG] laser posterior capsulotomy. Study Design: Quasi experimental study. Place and Duration of Study: Study was conducted in department of Ophthalmology, Combined Military Hospital Peshawar of six months duration from Oct 2013 to Mar 2014

Material and Methods: A total of 182 patients were included in this study. One drop of 0.2% brimonidine one hour prior to laser treatment was instilled in the eyes of patients. Cornea was anaesthetized with topical 0.5% proparacaine hydrochloride. "Ocular instruments ® Abraham Capsulotomy YAG contact lens" was used along with Q-switched Zeiss VISULAS YAG III [Nd: YAG] laser system to make a hole of 3-4mm in the posterior capsule using minimum amount of total laser energy. Data were analyzed using SPSS version 15.0. Mean and standard deviation was calculated for numeric variables like age and intraocular pressure at different occasions. Frequency and percentage was calculated for categoric variable i.e. gender. Efficacy was stratified among age and gender to see effect modifiers

Results: The mean age of participants was 63.3 +/- 7.7 years. Out of 182 patients, 109 [59.9%] were male while remaining 73 patients [40.1%] were female. Brimonidine 0.2% eye drops proved effective in 162 patients [89.0%]. Stratification of age and sex with regard to efficacy of 0.2% brimonidine eye drops was carried out

Conclusion: The use of 0.2% brimonidine has been proven effective to counteract the IOP increase following Nd: YAG laser capsulotomy in this study

Hypoglycemia in small for gestational age neonates based on gestational age, gender, birth weight and mode of delivery

Objective: To determine the frequency of hypoglycemia in small for gestational age neonates based on gestational age, gender, birth weight and mode of delivery

Study Design: Cross sectional study

Place and Duration of Study: Neonatal Intensive Care Unit [NICU], Military Hospital Rawalpindi, from Dec 2011 to Jul 2012

Material and Methods: We included 383 small for gestational age [SGA] neonates admitted in NICU. Blood glucose levels were checked in all neonates. Variables included in study were gestational age, gender, birth weight and mode of delivery

Results: Out of 383 SGA neonates enrolled by non-probability consecutive sampling, 191 [49.87%] were males and 192 [50.13%] were females. Out of these 203 [53%] were preterm, 165 [43.08%] were delivered at term and 15 [3.92%] were post-term SGA neonates with mean gestational age of 34 weeks 5 days. Out of the total 383 SGA neonates 208 [54.31%] developed hypoglycemia during stay in NICU and 175 [45.69%] remained euglycemic

Extremely low birth weight [ELBW] neonates were at highest risk to develop hypoglycemia[82.35%]. It was seen that SGA neonates delivered by instrumental vaginal delivery had highest risk of developing hypoglycemia i.e. 20 [76.92] out of 26 neonates. Out of 103 vaginal deliveries 41 [39.81%] had hypoglycemia and out of 254 Caesarean section 147 [57.87%] had hypoglycemia

Conclusion: Low birth weight neonates delivered by instrumental vaginal delivery were found to be at a higher risk of developing hypoglycemia

Does use of multi-source feedback [MSF] affect the attitudes of postgraduate trainees: experience of a teaching hospital

Objective: To explore the affects of multi source feedback [MSF] on the attitudes of post-graduate trainees

Study Design: Prospective mixed method study

Place and Duration of Study: Department of Ophthalmology, Lahore General Hospital [LGH] and Postgraduate Medical Institute [PGMI] Lahore, from Jul 2012 to Jun 2013

Material and Methods: This prospective mixed method study was conducted in the Department of Ophthalmology, LGH and PGMI, Lahore from July 2012 to June 2013. Participants were FCPS trainees and raters were the consultants, postgraduate trainees, house officers, nursing and paramedical staff. Modified mini-PAT Questionnaire was used. Survey I was followed by Survey II conducted after three months to determine any change. SPSS version 20 was used and paired sample t-test was applied to compare residents' mean scores. A p-value <0.05 was considered significant

Results: Mean score for question 1-12 was 4.00 +/- 0.16 and 4.43 +/- 0.14 for survey I [before intervention] and survey II [post intervention] respectively. Mean difference in overall score from two surveys was 0.43 +/- 0.06, which was statistically significant [p-value=0.000] showing overall improvement in scores from survey I to survey II. The highest mean score was awarded to question number 7 i.e. trainee respects patient's confidentiality and lowest to question 4 i.e. ability to manage time effectively, in both surveys

Conclusion: There was improvement in practice if MSF was delivered in accurate and timely manner with maintenance of the confidentiality and facilitative feedback

Fixation of intertrochanteric intertrochanteric femoral fractures femoral fractures by dynamic hip screw

Objective: Aim of the study was to evaluate the results of DHS fixation union rate, complications and functional outcome

Study Design: Experimental / clinical trial study

Place and Duration of Study: This study was carried out at Bolan Medical Complex Hospital Quetta from January 2014 to December 2015

Materials and Methods: 45 patients were surgically treated with use of dynamic hip screw [DHS] to stabilize the intertrochanteric fractures. Out of total 45 patients 35 [74%] were males and 10[14%] females. Age ranged between 25 -71 years average 63.9 years. Most common mode of injury was mixed in 28 patients. All the cases were classified according to Jensen's classification. All the cases were performed under image use of 135' angle plate with hip screw

Results: Out of 45 patients 03 patients died, two in the hospital and I at home. It was observed that patients from rural areas arrived late [19.8 days] after their injuries and these from urban areas reached within two days and thus affected the reduction and operation time

Time lapse between the injury and operation was 11.7 days. Overall union time was 20.02 weeks

No nonunion was seen

Complications were seen in 12 patients

Conclusion: Excellent to good results were achieved in 96% of cases which concludes that DHS is bio-mechanically stronger and better implant for fixation of intertrochanteric fractures

Short term outcome of single stage anterior sagittal anorectoplasty in the management of rectovestibular fistula in female children

Objective: The objective of the study was to assess the short term outcome of single stage anterior sagittal anorectoplasty for the management of rectovestibular fistula in female children

Study Design: Descriptive, Case Series study

Place and Duration of Study: This study was conducted in the Department of Neonatal and Pediatric Surgery, Bahawal Victoria Hospital, Bahawalpur from November 2010 to November 2013

Materials and Methods: Total 151 female children from 1 month to 13 years with the diagnosis of recto vestibular fistula undergoing primary ASARP were selected. No covering colostomy was done in any case. All the patients who were previously operated for RVF, or colostomy done for RVF, and those with septicemia were excluded. All the cases were managed in the ward and short term outcome was assessed in terms of post-operative wound infection [noted at 72 hours after surgery], vaginal tear[assessed during surgery], hospital stay and operative time. Results: There were a total of 151 female patients with mean age of 17.53 +/- 27.12 months. Mean operative time in our study was 85.76 +/- 16.49 minutes and mean hospital stay was 5.31 +/- 2.33 days. All the patients were examined regularly till discharge from ward and looked for any wound infection and vaginal tear. Wound infection was seen in 24 [15.89%] and vaginal tear in 21 [13.91%] patients. Wound infection was managed by daily wound wash with normal saline and povidone iodine solution. Vaginal tear managed during surgery by repair with vicryl 5/0

Conclusions: This study concluded that the short term outcome in terms of mean operative time, hospital stay, wound infection and vaginal tear after single stage anterior sagittal anorectoplasty is satisfactory in recto vestibular fistula treatment in female children

Management of developmental dysplasia of hip in older children by triple procedure

Objective: To review the presentation and evaluate the radiographic and functional outcome of developmental dysplasia of hip [DDH] in older children treated by triple procedure surgery, consisted of open reduction, Salter Innominate Osteotomy [SIO], femoral shortening and derotation Osteotomy

Study Design: Observational / descriptive study

Place and Duration of Study: This study was conducted at the BMC Hospital Quetta from January 2013 to December 2015

Materials and Methods: We assess the efficacy and safety of underwent triple procedure treatment of DDH in older children. The study series comprising 22 patients [25 hips].Patients were classified pre-operatively according to the Tonnis Classification, and post-operative functional evaluation was performed using modified Mackay's scoring system, while radiographic assessment considered Severin scoring method

Results: The average age at presentation was 5.60 years and the male to female ratio was 2:46 months. While the average follow-up were 16.4 months. The final outcome was successful in 19 hips [76%] in 16 patients. Patients younger than 5-6 years of age had a better radiological and clinical outcome as compared to older children. Although in the outcome of clinical and radiological assessment there were no significant different between group-I and group-II

Conclusions: Late presentation of DDH is still common in Quetta, Balochistan, which necessitates Triple procedure operative management given frequent occurrences of best result in younger children. Early diagnosis and surgical interventions is therefore imperative in the successful treatment of patients suffering from DDH

profile of plasma concentration of adiponectin in primary school children in Dera Ismail Khan

The objective of the present study was to determine the plasma Adiponectin concentration in primary school children 6-11 years and to evaluate negative association of Adiponectin in obese children. This cross sectional study was carried out in the Department of Chemistry, Gomal University, Dera Ismail Khan from June 2007 to August 2010. A total number of 1336 primary school children were examined in the Municipality area of Dera Ismail Khan and excluding those suffering from chronic health problems. Height [m], weight [kg] of each child was taken and BMI was calculated according to Quatelet's Index. Body mass Status was also calculated through CDCs' Growth Charts 2002, 2-20years for children to have percentile for each school child. School children with >/= 5[th] percentile were declared normal weight and the ones having >/= 95[th] percentile as obese. 83 school children were randomly selected among 1336 children with 23 [27.71%] normal weight and 60 [72.28%] as obese ones. Gender wise distribution of the sample was 48 [57.83%] boys and 35 [42.16%] as girls. Fasting plasma adiponectin concentration was determined by ELIZA method. Mean plasma adiponectin concentration in normal weight children was noted as 21.38micro g/ml [P = 0.013] and 20.89micro g/ml [P = 0.011] in boys and girls respectively. The observed, mean plasma adiponectin level in obese children was 20.38micro g/ml [P =0.0130] and 25.56micro g/ml [P = 0.0016] in boys and girls respectively. Significant difference in plasma adiponectin concentration was observed between normal weight and obese girls

Caudal duplication syndrome

Complete duplication of genitourinary system, colon and vertebral column is a very rare and complex congenital condition termed as "caudal duplication syndrome" with variable presentations. This term is often quoted as a type of incomplete separation of mono-ovular twins or conjoined twinning. It is associated with other congenital malformations of the genitourinary, gastrointestinal and other organ systems. The hereby reported case, a 3-month-old male infant had presented with the classical form of the disease i.e., duplication of the gastrointestinal, genitourinary system and vertebral column with anterior abdominal wall hernia and a large lipomeningocele

Captain of all these men of death - tuberculosis remains the commonest diagnosis - two years experience of bronchoscopy at Shaikh Zayed hospital, Lahore

A retrospective study of two years duration was conducted at the department of Pulmonology, Shaikh Zayed Hospital, Lahore, Pakistan to review our experience with bronchoscopy. Data was collected from145 patients who underwent bronchoscopy for different diagnostic and therapeutic indications. The study participants were having ages between 13 and 93 years. There were 85 male and 60 female patients. Bronchoscopy was performed for diagnostic purposes in 124 [85%] patients, for therapeutic purposes in 9 [6%] patients and for surveillance of airways in 13 [9%] patients. Bronchoscopy remained diagnostic in 74.19% patients. Tuberculosis was the commonest diagnosis in 34.6% patients followed by malignancy which was diagnosed in 16.1% patients. In 82% patients there was no complication during procedure, while mild haemoptysis occurred in 11.72%, 5.5% had wheezing [bronchospasm], 4.1% developed low grade fever and 1 patient died due to respiratory failure. It was concluded that bronchoscopy is found to be a useful procedure and can be used safely for diagnoses and treatment of different respiratory diseases

Prevalence of sub clinical hypothyroidism in school children [6-11 years] of Dera Ismail Khan

To determine the prevalence of sub clinical hypothyroidism [hyperthyrotropinemia] in obese school children. This cross-sectional study was carried out in Department of Chemistry, Gomal university, Dera Ismail Khan, from June 2007 to August 2010 including eight primary schools of Dera Ismail Khan having mixed population with some of the wards belonging to high socioeconomic group. Thorough clinical examination excluded those suffering from chronic health problems. Height and weight of each child was taken according to standard anthropometric procedures. Body mass index and body mass status of each study subject was calculated according to Quetelet's Index and WHO criteria respectively. a total of 83 school children [6-11 years] were randomly selected among 1336 children. The sample included 23 [27.71%] normal weight children and 60 [72.28%] obese. Gender wise distribution of the sample was 48 [57.83%] boys and 35 [42.16%] girls. Free Thyroxin [FT] and Thyroid Stimulating Hormone [TSH] were measured using radioimmunoassay. Hyperthyrotropinemia was the most commonly observed thyroid hormone dysfunction [8.43%] in the whole sample [n=83] and 8.33% in obese children compared with 3-8% in general population of the United States. Sub clinical hypothyroidism is the most common finding in the childhood obesity. The prevalence of sub clinical hypothyroidism in the present study is 8.43% in the whole sample [n=83] compared with 3-8% in general population of the United States. It is suggested that all the obese children expressing minimum organ abnormalities be investigated to prevent the irreversible problems over the course of many years

Single incision Trans scrotal versus standard inguino-scrotal orchidopexy in children with palpable undescended testis: our experience from April 2007 to April 2010

To compare the efficacy and complications of single incision trans scrotal versus standard inguinal orchidopexy in children with palpable undescended testes. This randomized controlled trial was conducted at the Paediatric Surgery Department Bahawal Victoria Hospital Bahawalpur from April 2007 to April 2010. Children aged 9 months to 12 years, diagnosed as cases of palpable undescended testes were randomized into two groups. In group A orchidopexy was performed through single scrotal incision and in group B by standard two incision inguinal approach. The groups were compared for operative time, hospital stay, scrotal hematoma, wound infection, and secondary ascent. Each group had 134 cases. Mean operative time and hospital stay in group A and B were 28.32 +/- 0.92 minutes and 47.83 +/- 0.76 minutes [p value 0.0001] and 1.027 +/- 0.205 days and 3.023 +/- 0.203 days [p value 0.0001] respectively. There was no significant difference in the formation of scrotal haematoma, wound infection and secondary ascent of testis between the two groups. The conversion rate of surgery in group A was 7.46%.Trans scrotal orchidopexy is the simple, effective and less invasive technique as compared to the standard two incision inguinal approach.

Impact of transarterial chemoembolization on 1 year survival rate of patients suffering from non-resectable hepatocellular carcinoma

Treatment of nonresectable HCC remains unsatisfactory and different therapeutic regimes have been tested. Transarterial chemoembolization [TACE] is the most promising palliative modality for unresectable HCC and determination of the survival rates of patients after TACE is important to guide clinicians for proper management of advanced HCC. So objective of our study was to determine 1 year survival rate in patients with unresectable HCC treated by TACE. Retrospective Study. This study was conducted at Shaukat Khanum Cancer Hospital and Research Centre, Lahore from July 2009 to June 2010. 90 patients with unresectable HCC who underwent TACE treatment were identified from a prospectively collected database. Patient survival from the first TACE session was calculated at 6 and 12 months duration after TACE, with Kaplan-Meier analysis. A total of 90 patients were studied. All patients underwent TACE with appropriate technical measures. The age range of patients was 34 years to 84 years. Mean age of patients was calculated to be 59.67 years and median to be 58 yrs. 59 were males and 31 were females. In all 90 patients, none died because of the complications of TACE. 3 out of these 90 patients died within 6 months of procedure, while 11 died within 1 year. So this resulted in 14 patients out of 90 [15%], who could not survive after 1 year of TACE. 76 patients remained alive with survival rate of 84.4%. TACE is an effective treatment option for advanced unresectable HCC. Our study showed that, the overall survival benefit for such patients is tremendously improved if they are managed with TACE

Status of evidence based surgery among general surgeons

Objective: To see the status of EBM among general surgeons of Faisalabad and Gujranwala

Settings and methods: A survey was conducted among the general surgeons in December 2010 through a questionnaire comprising of 10 questions for which level 1evidence is available

Results: Out of 110 general surgeons who were distributed the questionnaire 96 responded. The correct response rate was only 31.25% [300/960]. Only two questions [Q4 and Q5] were answered correctly by a majority of the participants. There was no significant difference of correct response rate between teaching hospital based and non teaching hospital based general surgeons [31.59% vs. 30.61%]

Conclusion: The status of EBM among general surgeons seems to be disappointing and a great effort is required to develop its culture

Waist circumference and lipid profile among primary school children

To explore the association of lipids and lipoprotein levels with large waist circumference in obese primary school children of Dera Ismaii Khan. This study explores the frequency of adverse level of waist circumference in primary school children and associated high serum concentration of lipids and lipoproteins to identify children at risk for cardiovascular disease. The study involved 86 primary school children, [Obese: 61 [70.93%], Normal weight: 25 [29.06%]]. Adverse level of waist circumference [WC] was observed in 32% normal weight and 78.69% in obese children. Gender difference for higher level of WC, was observed in obese children [boys = 42%, girls = 36 .68%]. Higher level of lipids [Triglyceride and Total Cholesterol] and lipoproteins [High Density Lipoprotein Cholesterol and Low Density Lipoprotein Cholesterol] was noted in children with higher WC [Normal weight 6 [24%], Obese 48 [80%]] compared with children having low level of WC [normal weight <61cms and obese <71cm]. The adverse level of waist circumference was observed in most of the obese children and a higher level of lipids and lipoproteins was also noted in children with adverse level of waist circumference

Application of an external fixator to the open diaphyseal fractures of femur

The study on 30 cases of open diaphyseal femoral fractures has been done between January 2008 to November 2008 on patients coming to Orthopaedics Department at Bolan Medical complex Hospital Quetta attached to Bolan Medical College, Quetta. It is a prospective study, which includes 30 patients with open diaphyseal fractures of femur. They were operated after stabilization of general condition using external fixator. It is a valuable clinical treatment option, providing surgeons with the spatial relationship of tissues both statically and dynamically via minimally, technique. The study shows union occurred in 24, 80% cases. There was an established non-union in 06 [20%] cases. All were Type III-A and III-B. The average time of union was from 8-20 weeks. The overall incidence of deep infection was 38% and was limited to type III-A and III-B. Pin crack infection was seen in 36% and was controlled with standard management. The average hospital stat was 15 days On the basis of this study it is evident that treatment by external fixator is very satisfactory, cost effective and there are no major complications and can be used with full confidence. Above all good results can be achieved by aggressive and repeated debridement, irrigation and early soft tissue coverage of the-bone

Fixation of distal femoral fractures in adults by dynamic condylar screw

To analyze the role of Dynamic Condylar Screw and the early functional outcome and complications associated with surgical management of Distal Femoral Fractures in Adult using DCS in our circumstances. This descriptive study was carried out in Orthopaedics Department Bolan Medical Complex Hospital Quetta from March 2007 to April 2008. The study included management of 25 cases of Distal Femoral Fractures treated by Dynamic Condylar Screw. These fracture are complex injuries, which are often unstable and comminuted. Despite advances in surgical Technique and improvement in implant, treatment of Distal Femoral Fractures remains a challenge in many situation, if not treated correctly may lead to permanent disability. There were 25 cases selected, 23 males and 2 females with in average age of 32.2 years, ranging from 20 years to 60 years. The cause of injury was high-energy trauma in majority of cases. These were of A1, A2, A3, and C1 and C2 type fractures. 21 out of 25 cases gained knee flexion more than 90°. The limb shortening of 2cm was noted in 03 cases, in 20 patients fractures united in 10-12 weeks. Bone graft was used in 05 cases. The average follow up was about 10 months. At the end of the study results shows that DCS is a good method of treating closed type, A1, A2, A3, C1 and C2 fractures. DCS provides rigid fixation and good purchase in Osteoporotic bone. Early mobilization prevents knee stiffness

Hyperglycemic/diabetic condition in school children of Dera Ismail Khan

Hyperglycemia/Type-2 diabetes mellitus is becoming more common at a younger age because of obesity and inactivity in children. Hyperglycemia/Diabetes is more common in those with family history of diabetes mellitus. All overweight and obese individuals have insulin resistance but those with an inability to increase beta cell secretion of insulin, develop hyperglycemia/Type-2 diabetes mellitus. Total of 107 school children [6-11 years] were included in this study with 60 [56.07%] boys and 47 [43.93%] girls. 77 [77.96%] children were obese and 30 [28.04%] were normal weights. Thorough clinical examination excluded those with chronic health problems. Height and weight of each school child was taken. Body mass index was calculated according to Quatelet's Index BMI number of each child was plotted on the Centers for Disease Control and Prevention's [CDC] gender specific growth charts for 2-20 years to get BMI for-age percentile. Body mass index [underweight, normal weight, overweight and obese] was determined according to World Health Organization. Casual plasma glucose level was determined instantly after getting venous blood using Trendier-Reaction Casual plasma glucose level >200 mg/dl was taken as normal. Hyperglycemia/Type-2 diabetes mellitus is diagnosed when symptoms of diabetes mellitus and casual plasma glucose concentration is >200 mg/dl. 150 mg/dl was the maximum concentration of casual plasma glucose without any associated symptoms [polyuria, polydipsia and polyphagia] of diabetes mellitus. None of the child was suffering from hyperglycemia/ Type 2 diabetes mellitus. Early detection of hyperglycemia/Type-2 diabetes mellitus may reduce the micro and macro-vascular complications in undiagnosed cases especially in children with obesity and family history of Type-2 diabetes mellitus

Body mass status of school children of Dera Ismail Khan, Pakistan

Childhood obesity is a global epidemic involving both developed and developing countries. It is a stare of over-nutrition with long term complications such as dyslipidemia, hypertension, and coronary artery disease and type-2 diabetes. Underweight is the result of under nutrition leading to reduction in growth and development of every body organ especially the Central Nervous System. Long term under-nutrition causes failure in linear growth [height] of the child. Growth is further retarded by the repeated attacks of respiratory infections, diarrhea and anemia as a result of reduced immunity. This study was carried out eight primary schools of Dera Ismail Khan [Private, semi government organizations, and welfare foundations] having mixed population with some of the wards belonging to high socioeconomic group. Thorough clinical examination excluded those suffering from chronic heath problems. Height and weight of each one was taken body mass index of determined according to 'Quatelet's' index. Body mass index number was plotted on the CDC S age and gender specific growth charts 2-20 years for BMI-for age percentile and body mass status [underweight, normal weight, overweight/at the risk of overweight and obese/overweight. Total 1338 school going children [6-11years] were examined with 865 [67.75%] boys and 471 [35.25%] as girls. 13.39%, 72.15%, 8.83% and 5.61% as underweight, normal weight, overweight and obese respectively. Percentage of underweight was higher in girls [25%] than boys [13.22]. Percentage of obesity was higher [5.17%] in boys than girls [1.39%]. Awareness about balanced diet, improvement in the level of education and socioeconomic conditions, easy access to health facilities and prevention of the gender discrimination, are the remedial measures to be taken to redress the situation